I don't watch MADTv, so I checked out their website
to see what they're doing. Didn't help much. Seems they do an incredible variety of things.
It's possible to do most of them in Moho ((http://www.lostmarble.com) but probably not fast or in a single step. Some effects would require using another graphics editor too. Moho isn't really set up to do quick video stuff.
Maybe someone else knows a better program.
Fav quote - "Experience is whatcha don't get 'till ya don't need it no more."
System - Athlon 1.4GHz, Win98, Hauppauge PVR250 receiver and compressor.
Software -Magix Movie Edit Pro 10, Nero 6 + NeroVision Express, Moho 4.61, PSP 8.1, Bryce, Quicktime 6.52 pro, Goldwave 5, DVD-Lab.
Cameras - Panasonic GS9, Canon ES8400V, Canon EOS D20 and Canon A70