When you're doing a small or a big project, you simply must get this right in my opinion. Currently, i'm working myself on a project with [URL="http://nl.wikipedia.org/wiki/Dolby_Digital"]5.1 surround sound[/URL], and it started out as a big mess. I'm working in Adobe Premiere CS6, so you can imagine the GUI.
I started out with the clip and audio on track #1. I use track #2 as another audiotrack for voice, when it is underneath another clip. track #3, #4 and #5 are ment for